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Research and Development

Arvinas scientific staff preparing materials for testing

Working to Bring New Medicines to Patients to Address Immediate Unmet Needs

Arvinas is dedicated to advancing comprehensive programs in oncology and neurodegeneration, including against targets that have traditionally been deemed “undruggable.”

Arvinas scientific staff preparing materials for testing
Image of protein test vial
Arvinas scientific staffer looking into microscope

We Create PROteolysis Targeting Chimeras

We are engineering an expansive pipeline of proteolysis targeting chimeras, or PROTAC® protein degraders, designed to harness the body’s own natural protein disposal system (the ubiquitin proteasome system) to selectively and efficiently degrade and remove disease-causing proteins.

Our Research

Arvinas is currently the only targeted protein degradation company with investigational drugs nearing pivotal trials.

Arvinas scientific staffer reviewing test slides

Prostate Cancer

Bavdegalutamide (ARV-110) and ARV-766 are androgen receptor targeting PROTAC® protein degraders currently being investigated for the potential treatment of men with metastatic castration-resistant prostate cancer (mCRPC)

Arvinas scientific staff member preparing vials for testing

Breast Cancer

ARV-471 is an estrogen receptor targeting PROTAC® protein degrader currently being investigated for the potential treatment of patients with locally advanced or metastatic estrogen receptor (ER) positive / human epidermal growth factor receptor 2 (HER2) negative (ER+/HER2-) breast cancer 

Arvinas scientific staffer reviewing brain scans on monitor

Neuroscience

We are pioneering the discovery of PROTAC® protein degraders in neurologic diseases, which have historically been difficult to treat

Pipeline

Learn more about our pipeline and clinical programs

The agents listed above are currently under investigation. Their safety and effectiveness have not yet been established.

Smiling Arvinas scientific staff member talking with colleague
Arvinas scientific staff
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If you’re inspired, please take a look at the current list of opportunities to join our team.

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