Clinical Archives - Arvinas

01JunJune 1, 2026

Phase 1 Study of ARV-393, a PROTAC BCL6 Degrader, as Monotherapy in Patients With Advanced NHL or Combined With Glofitamab in Patients With DLBCL

21AprApril 21, 2026

Phase 1 Study of ARV-393, a PROTAC BCL6 Degrader, as Monotherapy in Patients With Advanced NHL or Combined With Glofitamab in Patients With DLBCL

08JanJanuary 8, 2026

Phase 1/2 Study of ARV-806, a PROTAC KRAS G12D Degrader, in KRAS G12D-mutated Advanced Solid Tumors, including Pancreatic Cancer

09DecDecember 9, 2025

Circulating Tumor DNA Biomarker Analyses of a Phase 1/2 Study Evaluating Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in ER+/HER2- Advanced Breast Cancer

09DecDecember 9, 2025

Real-world Prevalence of ESR1 Mutations Among Patients With ER+/HER2- Metastatic Breast Cancer After First-line Treatment With Endocrine Therapy and/or a CDK4/6 Inhibitor

09DecDecember 9, 2025

Subgroup Analyses of VERITAC-2: A Phase 3 Trial of Vepdegestrant, a PROTAC ER Degrader, vs Fulvestrant in ER+/HER2- Advanced Breast Cancer

15NovNovember 15, 2025

ARV-102, a PROTAC LRRK2 Degrader, Modulates Pathways Associated With Parkinson’s Disease and Progressive Supranuclear Palsy: Proteomic Analyses of CSF From Non-human Primates and Healthy Volunteers

17OctOctober 17, 2025

TACTIVE-N: Phase 2 Study of Neoadjuvant Vepdegestrant, a PROTAC Estrogen Receptor (ER) Degrader, or Anastrozole in Postmenopausal ER+/Human Epidermal Growth Factor Receptor 2-Negative Localized Breast Cancer

17OctOctober 17, 2025

Patient-Reported Outcomes (PROs) with Vepdegestrant (VEP) vs Fulvestrant (FUL) in Patients (pts) with Estrogen Receptor (ER) 1 Gene Mutated (ESR1m) ER+/Human Epidermal Growth Factor Receptor 2 (HER2): Advanced Breast Cancer (aBC) in the Phase 3 VERITAC-2 Trial

05OctOctober 5, 2025

First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of ARV-102, a PROTAC LRRK2 Degrader, in Healthy Participants