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  • Our Science
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15MayMay 15, 2024

TACTIVE-K: Phase 1b/2 Study of Vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) Estrogen Receptor Degrader, in Combination With PF-07220060, a Cyclin-Dependent Kinase 4 Inhibitor, in Estrogen Receptor+/Human Epidermal Growth Factor Receptor 2- Advanced Breast Cancer

03MayMay 3, 2024

ARV-766, a PROTAC Androgen Receptor Degrader, Combined With Abiraterone in Novel Hormonal Agent–Naïve Metastatic Prostate Cancer: Phase 1 Cohort (Part C) of a Phase 1/2 Study

05AprApril 5, 2024

The Discovery of ARV-393, a Potent, Orally Bioavailable BCL6-Targeting PROTAC® for the Treatment of NHL

27MarMarch 27, 2024

The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) Estrogen Receptor Degrader in Healthy Adult Participants

27MarMarch 27, 2024

The Effect of Vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) Estrogen Receptor Degrader, on Dabigatran Pharmacokinetics in Healthy Adult Participants

27MarMarch 27, 2024

Evaluation of the Effect of Vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) Estrogen Receptor Degrader, on Rosuvastatin Pharmacokinetics in Healthy Adult Participants

27MarMarch 27, 2024

Drug-Drug Interaction Study of the PROteolysis TArgeting Chimera (PROTAC) Androgen Receptor Degrader Bavdegalutamide in Combination With the P-glycoprotein Substrate Fexofenadine in Healthy Male Volunteers

25JanJanuary 25, 2024

Real-World Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Tumors Harboring Androgen Receptor (AR) Ligand-Binding Domain (LBD) Mutations

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