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Open Positions: Targets to Leads Chemist

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit

Position Summary

Arvinas has an exciting opportunity in our Targets to Leads Chemistry team for a medicinal chemist who has a demonstrated track-record of contributing to research projects towards IND-track nomination and strong collaboration skills partnering with internal and external stakeholders.

This position reports to the Senior Director, Targets to Leads Chemistry and will be located at our headquarters in New Haven, CT. Hybrid work arrangements are available, with 1 - 2 days a week being remote based on work requirements and project needs.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Effective management of assigned Target to Leads projects in line with target project profiles and timelines within a team environment
  • Driving hit chemical matter to lead chemical matter in an expeditious fashion. Effective interface with biophysics is to be expected.
  • The expeditious molecular and synthetic design of ligands and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensuring that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • Providing transparent, coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed


  • A medicinal chemist with 10+ years of pharma/biotech-based drug discovery experience, with a track-record of contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A medicinal chemist with extensive track record triaging chemical hits from biochemical and cell based screening platforms. Proven track record of progressing chemical hits to lead matter. Experience with SpotFire and other chemo-informatics platforms required.
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas


  • MS or PhD in Organic Chemistry or related scientific discipline.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity employer

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