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Open Positions: Co-Op: Neurodegeneration - Tri-culture model of Parkinson’s disease (PD)

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes two clinical-stage programs: ARV-110, which is being developed as a potential treatment for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 200 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit www.arvinas.com.

Position Summary

Join the exciting and growing Neuroscience and Platform teams at Arvinas in New Haven, CT. Arvinas is a pharmaceutical company focused on developing new small molecules – known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders – aimed at degrading disease-causing cellular proteins via proteolysis. Based on the innovative research conducted at Yale University by founder Craig Crews, Arvinas is translating natural protein degradation approaches into novel drugs for the treatment of cancer neurodegeneration and other diseases. This position will perform work the neuroscience induced-pluripotent stem cell (iPSC) group and in the Functional Area Support Team (FAST).

This position will be located at our headquarters in New Haven, CT.

Principal Responsibilities

In the iPSC group the candidate will learn to generate large quantities of induced-neurons (iNs) from patient-derived iPSCs for cryopreservation and applying these cells to in vitro model of Tauopathies and Synucleinopathies. Training will be provided on multiple fronts including: the cryobanking of cells, QC of iNs (high content image analysis, immunocytochemistry, and Nanostring). The incumbent will have the opportunity to outline and optimize our iN-production process and subsequent quality control and reporting.

In the FAST group the candidate learn the process of evaluating the activity of large numbers of lead-molecules using 384-well plates in a dose-response format, using automated methods for liquid-transfer and data analysis. They will also undertake a project to validate 384-well cultures of CNS cell types in tri-cultures (neurons, astrocytes, and microglia) using methods established by outside groups and treat with agents inducing disease pathology as well as therapeutic agents effecting drug targets of interest to Arvinas. Analytical assays on these cultures will include fluorescent microscopy and high-content screening (HCS).

The candidate will also be expected to independently analyze and communicate experimental data to team members, write up experimental procedures for colleagues, and provide thorough documentation using an electronic lab notebook. This streamlined process will ultimately be transferred to the Neuroscience and Platform teams to be incorporated into a routine workflow.

Qualifications

  • Attentive to detail
  • Persistent and goal-oriented
  • Capable of independent work and communicate progress or problems
  • Open to constructive feedback, and freely asks questions
  • Basic understanding of cell-based assays
  • Interest in applying analytical and statistical methods to cell biology
  • Prior experience with cell culture desired, but not a pre-requisite

Education

Current academic junior or senior enrolled in undergraduate degree program with a concentration in biology, neurology, or scientific related field.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer

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