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Open Positions: Associate Scientist/ Research Scientist, Biology

Arvinas is a clinical-stage biopharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis Targeting Chimera) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. Our proprietary PROTAC®-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Position Summary

This position is laboratory/wet bench based and requires strong experimental technique, the ability to deliver quality data in a timely manner from high throughput cell-based assays and work effectively with team members in support of small molecule drug discovery efforts. Data analysis and interpretation is required, as will be method development where appropriate. This position reports to a Research Investigator within the Biology department and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, high content IF cell imaging, cell viability/death utilizing small molecules to generate full dose response curves
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Perform molecular techniques including DNA/RNA isolation, cloning, PCR, RT-PCR, qRT-PCR, gene expression analysis, cell line engineering as needed
  • Identify and characterize appropriate cell models that are dependent on the target of interest
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression, present data at regular team meetings
  • Document, compile and interpret experimental data; manage laboratory notebook, databases, and/or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

Qualifications

  • Proficiency in aseptic tissue culture techniques and mammalian cell tissue culture is required
  • Experience with protein lysate preparation from cells and tissues, and quantitative Western blotting is required
  • Molecular techniques including DNA/RNA isolation, cloning, and PCR/RT-PCR/qRT-PCR is required
  • Experience in cellular functional assays such as cytotoxicity, apoptosis, and siRNA/shRNA transfection is preferred
  • Experience working with small molecules to generate full dose response curves in drug discovery is preferred
  • Development and optimization of high throughput (96/384 well) cell-based assays using a variety of readout technologies (e.g. fluorescence, luminescence, AlphaLISA) is preferred
  • Experience with various bioassays such as High content IF imaging, ELISA, multiplex protein analysis is preferred
  • Excellent data handling and recording skills as well as oral and written communication skills is required
  • Ability to work as a team player and be able to work on several projects simultaneously
  • General knowledge of cancer biology is preferred
  • Proficiency in execution and data analysis in the following is a plus;
    • TR-FRET
  • flow cytometry
  • 2D/3D cellular proliferation assays
  • CRISPR knockdown assays
  • Organized, goal-oriented and timeline-conscious with the ability to plan, work and problem-solve independently while under general supervision by the project leader
  • A strong work ethic and willingness to learn drug discovery approaches and apply them in cell biology and other techniques is required.
  • BS with 8+ years experience or MS in Biology or relevant discipline with 3+ years experience

Education

  • BS with 8+ years experience or MS in Biology or relevant discipline with 3+ years experience


Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families. Benefits include group medical, vision, and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com.

Arvinas is an Equal Opportunity Employer.

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