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Open Positions: Associate Director, Oncology Translational Science, Clinical Biomarkers

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit

Position Summary

We are seeking a candidate who is passionate about advancing novel cancer therapies into the clinic to help drive the translational strategy for our expanding portfolio of clinical stage PROTAC drug candidates. This highly motivated and seasoned scientist will use their translational science expertise to interface with preclinical and clinical program teams and external partners to develop and implement pharmacodynamic and patient selection biomarker strategies for clinical studies.

This position reports to the Executive Director, Oncology Translational Science and can be remote, hybrid, or located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Serve as a subject matter expert for oncology translational science and clinical biomarkers
  • Work cross-functionally to develop and implement translational study plans, clinical biomarker and companion diagnostics strategies
  • Contribute to the overall development strategy
  • Communicate project deliverables to the leaders across the oncology therapeutic area and other senior governance groups when necessary
  • Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects to execute clinical biomarker studies and identify and implement new biomarker assay platforms/technologies
  • Contribute to clinical study protocols, investigator brochures, and regulatory filings
  • Participate in/contribute to external presentations, including scientific meetings, SIVs and manuscripts


  • Solid understanding of cancer biology and/or immuno-oncology is required
  • At least 5 years of drug development experience, including a solid understanding of the drug development process and particularly clinical trial design and execution, is preferred
  • Broad knowledge of technical platforms that include IHC, immunoassay, PCR, NGS and novel assay technologies (e.g., digital pathology, liquid biopsy, multiplex technologies)
  • Understanding of clinical biomarker investigation including biomarker operations and data management
  • Understanding of IVD development including all related analytical and clinical validation requirements
  • Demonstrated success leading translational studies, working on cross-disciplinary development teams, and integrating and evaluating the work of multiple drug discovery groups/functions
  • Recognition as an emerging leader in field with sustained performance and accomplishment, including publications in top tier journals, is required
  • Outstanding verbal and written communication skills are essential


  • Ph.D. in biochemistry, cell or molecular biology, pharmacology, or related fields with a minimum of 8+ years related experience which includes 2-4 years of academic or industry post-doctoral experience


Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity employer

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